Many of these actresses are used to looking drop dead gorgeous, but some of them had to get down and dirty for their film roles. Some gained weight and shaved their heads, and others went to different extremes to nail some of their most important roles.
Hilary Swank — Maggie Fitzgerald, Million Dollar Baby

Mayim Bialik — Amy Farrah Fowler, The Big Bang Theory

Gwendoline Christie — Brienne of Tarth, Game of Thrones

Anne Hathaway — Fantine, Les Misérables

Penélope Cruz — Italia, Don’t Move

Mia Wasikowska — Jane Eyre, Jane Eyre

Margot Robbie — Harley Quinn, Suicide Squad

Renée Zellweger — Bridget Jones, Bridget Jones: The Edge of Reason

Cynthia Nixon — Vivian Bearing, Wit (a one-act play)

Helena Bonham Carter — a witch, Big Fish

America Ferrera — Betty Suarez, Ugly Betty

Kate Winslet — Hanna Schmitz, The Reader

Eden Sher — Sue Heck, The Middle

Natalie Portman — Evey Hammond, V for Vendetta

Hilary Swank — Maggie Fitzgerald, Million Dollar Baby

Mayim Bialik — Amy Farrah Fowler, The Big Bang Theory

Gwendoline Christie — Brienne of Tarth, Game of Thrones

Anne Hathaway — Fantine, Les Misérables

Penélope Cruz — Italia, Don’t Move

Mia Wasikowska — Jane Eyre, Jane Eyre

Margot Robbie — Harley Quinn, Suicide Squad

Renée Zellweger — Bridget Jones, Bridget Jones: The Edge of Reason

Cynthia Nixon — Vivian Bearing, Wit (a one-act play)

Helena Bonham Carter — a witch, Big Fish

America Ferrera — Betty Suarez, Ugly Betty

Kate Winslet — Hanna Schmitz, The Reader

Eden Sher — Sue Heck, The Middle

Natalie Portman — Evey Hammond, V for Vendetta

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